Hemostatic microspheres

摘要

Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. In another embodiment, the hemostatic composition comprises an additive such as a wetting agent, a suspending agent, or both. The hemostatic compositions may also include a hemostatic agent such as thrombin, and may include a high concentration of thrombin. The hemostatic compositions may also include plasma. Also provided herein are devices for dispersing said hemostatic compositions in a diluent, and delivering said dispersed hemostatic composition. The hemostatic compositions may also fabricated with a selected geometry as administration suggests.

主权项

1. A hemostatic composition comprising a plurality of porous gelatin microspheres, thrombin, a wetting agent, and a suspending agent;
wherein the wetting agent and the suspending agent are present in a ratio of microspheres:the wetting agent and the suspending agent of 3:1 to 60:1 (w/w); wherein the gelatin is cross-linked gelatin; wherein the porous gelatin microspheres have a diameter from about 50 μm to about 500 μm, inclusive, when fully hydrated; wherein the porous gelatin microspheres contain pores having a pore diameter from about 15 μm to about 25 μm, inclusive; wherein the thrombin concentration is in a range of about 1,000 IU to about 2,000 IU per mL of rehydrated microsphere gel and a high level of thrombin is released from the hemostatic composition to yield a homogenous clot; wherein the hemostatic composition, when fully hydrated, remains flowable for at least 90 minutes, and wherein the wetting agent is poloxamer 188 and the suspending agent is carboxymethylcellulose.