Crystalline forms of afatinib di-maleate

摘要

The present disclosure encompasses crystalline forms of Afatininb di-maleate and methods of their use.

主权项

1. A crystalline form of Afatinib di-maleate, wherein the crystalline form is:
a crystalline form of Afatinib di-maleate designated as form Alpha, characterized by data selected from one or more of the following: X-ray powder diffraction pattern having peaks at 6.6, 10.6, 15.3, 16.3 and 24.2 degrees two theta±0.2 degrees two theta; an X-ray powder diffraction pattern as depicted in FIG. 7; a solid state 13C NMR spectrum with signals at about 171.6, 129.6, 102.4 and 79.0±0.2 ppm; a solid state 13C NMR spectrum as depicted in FIG. 17; and combinations of these data.