发明名称 |
Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods |
摘要 |
A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters. |
申请公布号 |
US9632060(B2) |
申请公布日期 |
2017.04.25 |
申请号 |
US201313778473 |
申请日期 |
2013.02.27 |
申请人 |
MEDTRONIC MINIMED, INC. |
发明人 |
Shah Rajiv;Mucic Robert C.;de Barros Genival D.;Callirgos Carlos A.;Sirigiri Manjunath;Brinson Joseph Paul |
分类号 |
G01N27/416;G01N27/02;G01R35/00;A61B5/145;A61B5/1473;A61B5/1495;G01N33/66;A61B5/1459;A61M5/158;A61B5/1486;A61B5/00;A61B5/053;A61M5/172;A61M5/142 |
主分类号 |
G01N27/416 |
代理机构 |
Pillsbury Winthrop Shaw Pittman LLP |
代理人 |
Pillsbury Winthrop Shaw Pittman LLP |
主权项 |
1. A method of testing the surface area characteristics of an electroplated electrode of an electrochemical glucose sensor, comprising:
performing an electrochemical impedance spectroscopy (EIS) procedure to obtain a value of an impedance-related parameter for said glucose sensor electrode, wherein the impedance-related parameter is imaginary impedance; correlating said obtained value to said glucose sensor electrode's electrochemical surface area; based on said correlation, determining lower and upper threshold values for said value of the imaginary impedance; and determining whether the glucose sensor electrode is acceptable for measuring glucose in a body of a subject, wherein said determination is made based on whether said value of the imaginary impedance falls within said lower and upper threshold values and is indicative of a number of low start-up events for the glucose sensor that is below a low start-up event threshold. |
地址 |
Northridge CA US |