Treatment of penetrative injury to the brain

摘要

The invention provides methods of treatment or prophylaxis of damaging effects of penetrative injury to the brain or other part of the central nervous system. The methods are based in part on results in a rodent model of penetrative ballistic injury showing that an inhibitor of PDF-95 NMDAR interaction is effective in inhibiting neurological deficits resulting from such injury. The methods are useful for treating subjects having or at risk of penetrative brain injury, including subjects who have been shot in the head or at risk of such injury (e.g., military or law enforcement personnel).

主权项

1. A method of treating or effecting prophylaxis of a damaging effect of penetrative ballistic injury to the CNS, comprising administering to a subject having or at statistically significant risk of penetrative ballistic injury to the CNS relative to the general population a pharmacological agent that inhibits binding of PSD-95 to an NMDAR and/or of PSD-95 to nNOS at a dose of 0.1 to 10 mg/kg and the administering inhibits development of cognitive deficits in the subject, wherein the pharmacological agent comprises a peptide having an amino acid sequence comprising T/SXV/L linked to an internalization peptide.