发明名称 |
Derivative of homoserine lactone, and preparation method and use thereof |
摘要 |
A derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.; |
申请公布号 |
US9630939(B2) |
申请公布日期 |
2017.04.25 |
申请号 |
US201314766680 |
申请日期 |
2013.12.10 |
申请人 |
INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA |
发明人 |
Li Song;Xiao Junhai;Zhao Mingming;Zhong Wu;Wang Lili;Zheng Zhibing;Xie Yunde;Li Xingzhou;Zhao Guoming;Zhou Xinbo;Wang Xiaokui;Chen Wei |
分类号 |
C07D307/33;A61K31/365;A61K45/06 |
主分类号 |
C07D307/33 |
代理机构 |
Banner & Witcoff, Ltd. |
代理人 |
Banner & Witcoff, Ltd. |
主权项 |
1. A derivative of homoserine lactone represented by formula I, a racemate or optical isomer, a pharmaceutically acceptable salt, a solvate or a hydrate thereof, wherein R is C1-12 linear or branched alkyl, or phenyl, said alkyl or phenyl is optionally mono-substituted or multi-substituted by a substituent selected from the group consisting of: (a) phenyl, (b) substituted or unsubstituted C1-5 linear or branched alkyl, (c) halogen, (d) cyano, (e) trifluoromethyl, (f) hydroxyl, (g) nitro, and (h) substituted or unsubstituted C1-5 alkoxyl. |
地址 |
Beijing CN |