Cysteine, N-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions thereof, and methods of use

摘要

Cysteine, N-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions comprising the cysteine, N-acetylcysteine, and penicillamine related compounds, and methods of using cysteine, N-acetylcysteine, and penicillamine related compounds and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including paracetamol overdose, non-alcoholic steatohepatitis, Wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial lung disease, asthma, cystic fibrosis, Parkinson's disease, and Huntington's disease.

主权项

1. A compound according to Formula (I):or a pharmaceutically acceptable salt thereof, wherein:
each R1 is chosen from hydrogen and methyl; R2 is chosen from hydrogen, C1-6 alkyl, C3-12 cycloalkyl, and C5-10 aryl; W1 is chosen from substituents of Formula (I-a) and Formula (I-b); and W2 is chosen from hydrogen and substituents of Formula (I-a), Formula (I-b), and Formula (I-c):wherein
R3, R4, R5, R6, and R7 are independently chosen from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, cyclohexyl, phenyl, and benzyl; andY1 is chosen from a bond and —O—.