发明名称 |
Shikonin, alkannin; and racemic parent nucleus cabonyl oxime derivatives and applications thereof |
摘要 |
A structural formula of a shikonin naphthazarin parent nucleus hydroxyl methylation carbonyl oxime derivative is shown in Formula (I) or (II); a structural formula of an alkannin naphthazarin parent nucleus hydroxyl methylation carbonyl oxime derivative is shown in Formula (III) or (IV); and a structural formula of a racemic shikonin naphthazarin parent nucleus hydroxyl methylation carbonyl oxime derivative is shown in Formula (V) or (VI), wherein R1 is alkane, olefin, arene, or substituting arene comprising 1 to 6 carbon atoms; and R2 is alkane, olefin, arene, or substituting arene comprising 1 to 6 carbon atoms or is H. The shikonin, alkannin, and racemic oxime derivatives of the present invention have novel structures, and in-vitro experiments show that the present invention has good growth inhibitory activity against tumor cells and can be used in tumor treatment. |
申请公布号 |
US9630912(B2) |
申请公布日期 |
2017.04.25 |
申请号 |
US201314759024 |
申请日期 |
2013.06.25 |
申请人 |
SHANGHAI JIAO TONG UNIVERSITY |
发明人 |
Li Shaoshun;Wang Rubing;Zheng Xiaogang;Zhang Xu |
分类号 |
C07C251/34;C07C251/46;C07C249/08;C07D213/79;C07D333/40;A61K31/15;A61K31/222 |
主分类号 |
C07C251/34 |
代理机构 |
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代理人 |
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主权项 |
1. A series of shikonin naphthazarin parent nucleus hydroxyl methylation carbonyl oxime derivatives, as shown in Formula (I) or (II): wherein R1 is alkane, olefin, arene, or substituting arene comprising 1 to 6 carbon atoms; and R2 is alkane, olefin, arene, or substituting arene comprising 1 to 6 carbon atoms or is H. |
地址 |
Shanghai CN |