TREATING BAX(DELTA)2-POSITIVE CANCER WITH CHEMOTHERAPIES TARGETING CASPASE 8

摘要

Discovery of a new Bax isoform, BaxΔ2, in cancer cell lines and primary tumors is described. The BaxΔ2 isoform resulted from combination of Bax microsatellite mutation and alternative splicing Bax exon 2. It is also discovered that BaxΔ2 renders cancer cells sensitive to certain chemotherapeutic drugs that target caspase 8. Also provided are methods for treating colorectal cancer by administering to a colorectal cancer patient a chemotherapeutic agent that is capable of activating caspase 8, wherein the patient contains a cancer cell that expresses a BaxΔ2 protein (SEQ ID NO. 2).

主权项

1. A method for identifying a colorectal cancer patient suitable for a therapy comprising a chemotherapeutic agent that is capable of activating caspase 8, wherein the chemotherapeutic agent is not doxorubicin, the method comprising detecting, in a cancer cell of the patient, the expression of a BaxΔ2 protein (SEQ ID NO. 2).