发明名称 |
ONCOLYTIC HETEROLOGOUS RECOMBINANT NEWCASTLE DISEASE VIRUS, PREPARATION METHOD AND APPLICATION THEREOF |
摘要 |
Provided are an oncolytic heterologous recombinant Newcastle disease virus (NDV), preparation method and application thereof. The heterologous recombinant NDV can express alpha (1,3) galactosyltransferase (α1,3GT). The α1,3GT is the protein represented by the flowing B1) and B2): B1) the protein has an amino acid sequence of SEQ ID No.1; and B2) the protein is derived from B1) and has a function of α1,3GT obtained by substituting and/or deleting and/or adding one or more amino acid residue(s) in the amino acid sequence represented by SEQ ID No.1. The recombination NDV can be used for tumor treatment. |
申请公布号 |
US2017106079(A1) |
申请公布日期 |
2017.04.20 |
申请号 |
US201615244006 |
申请日期 |
2016.08.23 |
申请人 |
Zhao Yongxiang |
发明人 |
Peng Xia;Peng Yi |
分类号 |
A61K39/17;C12N9/10;C12N7/00 |
主分类号 |
A61K39/17 |
代理机构 |
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代理人 |
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主权项 |
1. A recombinant Newcastle disease virus that has an expression of α1,3galactosyltransferase (α1,3GT). |
地址 |
Changsha CN |