METHODS OF INHIBITING PLATELET AGGREGATION AND PREVENTING THROMBOSIS USING ANTIBODIES THAT BIND (NA++K+)-ATPASE BETA SUBUNIT

摘要

Methods of inhibiting platelet activation and aggregation using peptide vaccine or antibodies that have binding specificity for the β subunit of the (Na++K+)-ATPase are provided, along with methods for inhibiting or preventing thrombosis in a subject using such peptide vaccine or antibodies.

主权项

1. A method of inhibiting thrombosis in a subject comprising administering an effective amount of pharmaceutical effective synthetic peptide vaccine, or a peptide derivative thereof, wherein the peptide vaccine stimulates the host immune system to generate antibodies that specifically bind to an epitope of the β1 subunit of the (Na++K+)-ATPase to a subject in need thereof, said epitope is represented by SEQ ID NOS: 1-6.