COMPOSITIONS AND METHODS FOR ENHANCING RED BLOOD CELL STORAGE TIME AND SURVIVABILITY USING NITRIC OXIDE RELEASING HYBRID HYDROGEL NANOPARTICLES

摘要

Described herein are hydrogel-based nanoparticles which release nitric oxide (NO) or other bioactive forms of NO including nitrosothiols, nitrofatty acids and dinitrogen trioxide into stored red blood cells (RBCs). Also provided herein is a method for using hydrogel-based nanoparticles to supplement stored RBCs with NO to enhance red blood cell (RBC) storage time, improve survivability in circulation, minimize toxicity associated with transfusion, and improve transfusion safety by eliminating infective organisms in stored blood.

主权项

1. A blood storage and/or rejuvenating composition comprising an anticoagulant and a hydrogel-based nanoparticle, wherein the nanoparticle releases nitric oxide (NO), nitrosothiol, nitrofatty acid, dinitrogen trioxide, a diazeniumdiolate (NONOate), or a combination thereof.