发明名称 |
FC CONTAINING POLYPEPTIDES WITH ALTERED GLYCOSYLATION AND REDUCED EFFECTOR FUNCTION |
摘要 |
Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced effector function. In particular embodiment, the Fc domain comprises: an asparagine residue at amino acid position 298, according to EU numbering; and a serine threonine residue at amino acid position 300, according to EU numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided. |
申请公布号 |
US2017107276(A9) |
申请公布日期 |
2017.04.20 |
申请号 |
US201414205264 |
申请日期 |
2014.03.11 |
申请人 |
Genzyme Corporation |
发明人 |
PAN Clark;QIU Huawei |
分类号 |
C07K16/18;A61K49/00;A61K47/48 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated binding polypeptide comprising an Fc domain with altered glycosylation, wherein the Fc domain comprises: an asparagine residue at amino acid position 298, according to EU numbering; and a serine or threonine residue at amino acid position 300, according to EU numbering, and wherein the binding polypeptide exhibits reduced effector function due to said altered glycosylation. |
地址 |
Framingham MA US |