MULTI-COMPONENT-MULTISTAGE MALARIA VACCINES

摘要

The present disclosure relates to novel malaria vaccines composed of different recombinant proteins, in particular recombinant fusion proteins comprising several different Plasmodium falciparum antigens from the pre-erythrocytic the blood, and the sexual parasite stages. The proteins and/or fusion proteins will be used in a mixture vaccine formulation to elicit protective immune responses in humans. Nucleic acid molecules encoding said recombinant proteins, vectors, host cells containing the nucleic acids and methods for preparation and producing such proteins; Antibodies induced or generated by the use of said malaria vaccines or said nucleic acid molecules encoding said proteins and/or fusion proteins and the use of such antibodies or recombinant derivatives for passive immunotherapy.

主权项

1. A mixture of recombinant proteins suitable as a human vaccine against the parasite Plasmodium falciparum comprising antigens from Plasmodium falciparum surface proteins of the pre-erythrocytic, the blood-, and the sexual-stage of the parasite life cycle, wherein
a) the pre-erythrocytic antigens comprise at least the antigens PfCelTOS, PfCSP and PfTRAP, or domains, variants or fragments thereof, and b) the blood stage antigen(s) comprise at least one or more variants of Apical membrane antigen 1 (PfAMA1), or fragments thereof; and c) the sexual stage antigen(s) comprise the ookinete antigen Pfs25 and/or the gamete/gametocyte surface protein Pf230C0, or variants or fragments thereof.