| 发明名称 |
ENGINEERED INVARIANT CHAIN MOLECULE FOR IMPROVED MHC CLASS I LOADING |
| 摘要 |
The present invention relates to peptides presented on the cell surface of cells in the MHC class I (MHC I) context in which the invariant chain has been engineered to favor loading of specific antigens and generate CD8+ T-cell activation |
| 申请公布号 |
US2017106066(A1) |
申请公布日期 |
2017.04.20 |
| 申请号 |
US201515317338 |
申请日期 |
2015.06.10 |
| 申请人 |
UNIVERSITETET I OSLO |
发明人 |
WÄLCHLI Sebastien P.;GREGERS Tone Fredsvik;INDERBERG Else Marit Suso;GAUDERNACK Gustav;KVALHEIM Gunnar;BAKKE Oddmund |
| 分类号 |
A61K39/00;C07K14/495;A61K9/00;C07K14/74 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nucleic acid molecule encoding a type II transmembrane invariant chain (Ii) which is modified by exchanging the class II-associated Ii peptide (CLIP) with an antigen. |
| 地址 |
Oslo NO |
