Method and System for Treating Gastro-Esophageal Reflux Disease (GERD)

摘要

A system and method for reducing the likelihood of GERD includes the modification of an individual's gut microbes in a manner that reduces, if not eliminates, the symptoms of GERD. Certain embodiments employ Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated system (CRISPR-Cas) or Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella 1 (CRISPR/Cpf1) system to render H. Pylori more susceptible to certain drugs, including antibiotics, thus addressing the antibiotic resistance otherwise experienced by treating H. Pylori with antibiotics.

主权项

1. A method for reducing the likelihood of GERD in an individual, comprising:
administering to an individual an amount of H. pylori modified by a CRISPR-Cas or Cpf1 system to render H. pylori more susceptible to antibiotics; permitting said modified H. pylori to become the dominant population of H. Pylori in the individual's stomach; and administering an effective amount of an antibiotic effective to kill the modified H.