COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER

摘要

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

主权项

1. A method for treating cancer comprising administering to a patient having cancer a therapeutically effective amount of a compound of formula ZZ:wherein
each R is independently hydrogen, halogen, allyl, or short alkyl; n is 1 or 2; R2 is hydrogen or short alkyl; R3 is hydrogen, halogen, alkyl, haloalkyl, allyl, alkenyl, alkenol, alkanol, or haloalkenyl; R4 and R5 are N; or R4 is N and R5 is C; or R4 and R5 is C; and A is oxygen or sulfur; or a salt thereof; wherein the cancer is thereby treated.