| 发明名称 |
METHODS AND COMPOUNDS FOR THE TREATMENT OF BONE LOSS AND/OR PAIN |
| 摘要 |
Bone loss and/or pain associated with an elevated activation of osteoclasts is prevented, treated and/or alleviated by the administration of an effective amount of a compound capable of inhibiting the activity of a peptidylarginine deiminase (PAD) enzyme. Methods and compounds for this use are disclosed, as well as diagnostic methods, kits, and a method for identifying compounds effective to prevent, treat and/or alleviate bone loss and/or pain. |
| 申请公布号 |
US2017105971(A1) |
申请公布日期 |
2017.04.20 |
| 申请号 |
US201615393335 |
申请日期 |
2016.12.29 |
| 申请人 |
CATRINA Anca;SVENSSON Camilla;KLARESKOG Lars;MALMSTROM Vivianne |
发明人 |
CATRINA Anca;SVENSSON Camilla;KLARESKOG Lars;MALMSTROM Vivianne |
| 分类号 |
A61K31/4184;G01N33/68;A61K31/166 |
主分类号 |
A61K31/4184 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for the treatment of bone loss and/or pain in a subject wherein said bone loss and/or pain is associated with an elevated activation of osteoclasts in said subject, wherein an effective amount of a compound capable of inhibiting the activity of a peptidylarginine deiminase (PAD) enzyme is administered to said subject. |
| 地址 |
Taby SE |
