| 发明名称 |
ANTIBODY DRUG CONJUGATES |
| 摘要 |
The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. |
| 申请公布号 |
US2017106095(A1) |
申请公布日期 |
2017.04.20 |
| 申请号 |
US201615291024 |
申请日期 |
2016.10.11 |
| 申请人 |
BATT David Bryant;Ettenberg Seth Alexander;Haubst Nicole;Hu Tiancen;Jenkins David;Toksoz Engin;Petropoulos Konstantin;Meyer Matthew John |
发明人 |
BATT David Bryant;Ettenberg Seth Alexander;Haubst Nicole;Hu Tiancen;Jenkins David;Toksoz Engin;Petropoulos Konstantin;Meyer Matthew John |
| 分类号 |
A61K39/00;C07K16/30;A61K31/506;C07K16/28;A61K45/06 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody drug conjugate of the formula
Ab-(L-(D)m)n or a pharmaceutically acceptable salt thereof; whereinAb is an antibody or antigen binding fragment thereof that specifically binds to both humanFGFR2 and FGFR4;L is a linker;D is a drug moiety;m is an integer from 1 to 8; andn is an integer from 1 to 10. |
| 地址 |
Wayland MA US |
