发明名称 AMINOPYRAZOLONE DERIVATIVE
摘要 The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors.;[Solution];The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.
申请公布号 US2017107207(A1) 申请公布日期 2017.04.20
申请号 US201515117701 申请日期 2015.02.17
申请人 DAIICHI SANKYO COMPANY, LIMITED 发明人 Ebisawa Masayuki;Suzuki Takashi;Haginoya Noriyasu;Hamada Tomoaki;Murata Takeshi;Uoto Kouichi;Murakami Ryo;Takata Takehiko
分类号 C07D405/14;C07D401/12;C07D401/14;C07D403/12;C07D401/04;C07D231/50;C07D405/12 主分类号 C07D405/14
代理机构 代理人
主权项 1. A compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a hydrogen atom, a C1-C6 alkyl group optionally having 1 to 3 substituents independently selected from group A given below, a C2-C6 alkenyl group optionally having 1 to 3 substituents independently selected from group A given below, or a C2-C6 alkynyl group optionally having 1 to 3 substituents independently selected from group A given below; R2 represents a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkyl group, or —CR21R22—(CR23R24)m—(CR25R26)n—(CR27R28)q—R29; m, n, and q each independently represent an integer of 0 or 1, whereinwhen m represents 0, n and q each represent 0, and when n represents 0, q represents 0;R21, R22, R23, R24, R25, R26, R27, and R28 each independently represent a hydrogen atom, a hydroxy group, a halogen atom, a cyano group, a C1-C6 alkyl group, or a C1-C6 alkoxy group, orR21 together with R22, R23 together with R24, R25 together with R26, and R27 together with R28 each independently optionally form an oxo group;R29 represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkoxy group, —NR291R292, —OR293, —COR294, or —SO2R294; R291 and R292 each independently represent a hydrogen atom, a C1-C6 alkylcarbonyl group optionally substituted by 1 to 3 halogen atoms, a C1-C6 alkoxycarbonyl group, a C3-C6 cycloalkyl group, a C1-C6 alkyl group optionally having 1 to 3 substituents independently selected from group B given below, or a phenyl-C1-C6 alkyl group optionally having, on the benzene ring, 1 to 3 substituents independently selected from group B given below;R293 represents a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a 5- or 6-membered aromatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, or a 5- or 6-membered aliphatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, whereinthe 5- or 6-membered aromatic heterocyclic group and the 5- or 6-membered aliphatic heterocyclic group are each optionally substituted by 1 to 3 C1-C6 alkyl groups;R294 represents a hydroxy group, a C1-C6 alkoxy group, a phenyl group optionally having 1 to 3 substituents independently selected from group B given below, —NR296R297, or —OR293; R296 and R297 each independently represent a hydrogen atom, a C3-C6 cycloalkyl group, or a C1-C6 alkyl group optionally having 1 to 3 substituents independently selected from group B given below, orR296 and R297 optionally together form a 3- to 6-membered aliphatic heterocyclic ring optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom; R3 represents a hydrogen atom, a halogen atom, a hydroxy group, a C1-C6 alkyl group, or a C1-C6 alkoxy group; R4 and R5 each independently represent a hydrogen atom, a hydroxy group, a halogen atom, a C1-C6 alkyl group optionally having 1 to 3 halogen atoms, a C1-C6 alkoxy group, or a C1-C6 alkylcarbonyloxy group, or R4 and R5 optionally together form a 3- to 6-membered cycloalkyl ring, or a 5- or 6-membered aliphatic heterocyclic ring optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom; W represents any of the following W1 to W3: (* binds to R7); R6 represents a phenyl group optionally having 1 to 5 substituents independently selected from group D given below, a C3-C7 cycloalkyl group optionally having 1 to 3 substituents independently selected from group D given below, or a 5- or 6-membered aromatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, wherein the 5- or 6-membered aromatic heterocyclic ring optionally has 1 to 4 substituents independently selected from group D given below; and R7 represents a phenyl group optionally having 1 to 5 substituents independently selected from group C given below, a naphthyl group optionally having 1 to 7 substituents independently selected from group C given below, a 5- or 6-membered aromatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, an 8- to 10-membered bicyclic aromatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, or an 8- to 10-membered bicyclic partially unsaturated-ring aliphatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, wherein the 5- or 6-membered aromatic heterocyclic group, the 8- to 10-membered bicyclic aromatic heterocyclic group, and the bicyclic partially unsaturated-ring aliphatic heterocyclic group each optionally have 1 to 4 substituents independently selected from group C given below: group A consists of a hydroxy group, a C1-C6 alkoxy group, an amino group, a C1-C6 alkylamino group, a di-C1-C6 alkylamino group, and a 5- or 6-membered aliphatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, group B consists of a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group, and a C1-C6 alkoxy group, group C consists of a halogen atom, a hydroxy group, a C1-C6 alkyl group, a C1-C6 alkoxy group optionally substituted by 1 to 3 halogen atoms, a C1-C6 alkoxy-C1-C6 alkyl group, a C3-C6 cycloalkoxy group, a C1-C6 alkoxy-C1-C6 alkoxy group, and an oxy group bonded to a 3- to 6-membered aliphatic heterocyclic group optionally having, in the ring, 1 to 3 heteroatoms independently selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, and group D consists of a halogen atom, a C1-C6 alkyl group optionally substituted by 1 to 3 halogen atoms, and a C1-C6 alkoxy group.
地址 Tokyo JP