| 主权项 |
1. Functionalized dendritic nanoprobes of the following formula (I)wherein:
for generation 1, R4 and R6 represent independently from each other a chain composed of oligoethyleneglycol patterns, at least one of said oligoethyleneglycol chains being functionalized at its extremity by a group chosen among a fluorophore, or a biocompatible dye, and R5 represents an hydrogen atom or a chain composed of oligoethyleneglycol patterns, said chain being optionally functionalized at its extremity by a group chosen among or a biocompatible dye, for higher generations, R5 represents an hydrogen atom and R4 and R6 represent a dendritic structure (D)m comprising at least one ether of benzyl alcohol, said benzyl being substituted either at positions 3, 4, and 5, or at positions 3 and 5, by chains composed of oligoethyleneglycol patterns, at least one of said oligoethyleneglycol chains being functionalized at its extremity by a group chosen among a fluorophore, or a biocompatible dye, and m=1, 2 or 4, X represents a group of the following formula (II): wherein p is from 3 to 6 and wherein the mean diameter of the nanoprobe is from 2 to 60 nm. |
