Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same

摘要

A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

主权项

1. A medical device comprising:
an array of microneedles; and a coating on or within at least a portion of the microneedles, wherein the coating comprises:
a peptide therapeutic agent; andan amino acid,wherein the peptide therapeutic agent and the amino acid both have a net positive charge, andwherein the peptide therapeutic agent is a parathyroid hormone-related protein analogue represented by formula [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.