Polymeric composition for ocular devices

摘要

Polymeric and co-polymeric compositions useful for preparing ophthalmic and ocular devices, such as implantable intraocular lenses (IOL) and contact lenses, and processes of forming the compositions and devices are provided. The disclosed polymeric or co-polymeric composition may include a curcuminoid compound as a UV-blocker, and is derived from a pre-polymerization mixture of monomers which comprises at least 50 weight percents acrylate monomers and exhibiting visible light transparency and ultraviolet light opacity. The disclosed co-polymeric composition may alternatively, or in addition, be derived from a pre-polymerization mixture of defined monomers.

主权项

1. A co-polymeric composition comprising a polymeric backbone composed of a plurality of backbone units covalently linked to one another, said backbone units being derived from a pre-polymerization mixture of monomers which comprises:
a first aromatic acrylate monomer, characterized as forming a first homopolymer having a refractive index that ranges from 1.50 to 1.53; a second aromatic acrylate monomer, characterized as forming a second homopolymer having a Tg lower by a range of 2° C. to 30° C. than a Tg of said first homopolymer; a third monomer, characterized as forming a third homopolymer having a Tg lower than 35° C.; a fourth monomer, characterized as forming a fourth homopolymer which is capable of absorbing water to at least 20% of the total weight of said fourth homopolymer; and a fifth monomer, being a crosslinking monomer, wherein: a concentration of said first aromatic acrylate monomer ranges from 50% to 60% of the total weight of the composition; a concentration of said second aromatic acrylate monomer ranges from 15% to 20% of the total weight of the composition; a concentration of said third monomer ranges from 10% to 15% of the total weight of the composition; a concentration of said fourth monomer ranges from 5% to 10% of the total weight of the composition; a concentration of said fifth monomer ranges from 2% to 5% of the total weight of the composition; and the composition is characterized by a glass transition temperature not higher than 5° C. and being formulated for ophthalmic application, wherein the composition is characterized by at least one of: a loop pull force mechanical strength of at least 60 grams; a Shore A hardness that ranges from 77 to 80; and an unfolding time of less than 6 seconds.