Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs

摘要

Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.

主权项

1. A method of treating small ischemic injuries in a patient, comprising administering to the patient an effective amount of an inhibitor of Factor XII (FXII) to treat the small ischemic injuries, wherein the administering is performed before, during, and/or after a medical procedure in the patient comprising contact with at least one of:
(a) the patient's heart, (b) at least one blood vessel in the patient chosen from: the aorta, the aortic arch, a carotid artery, a coronary artery, brachiocephalic artery, vertebrobasilar circulation, intracranial arteries, renal artery, a hepatic artery, a mesenteric artery, and/or a blood vessel of the arterial system cranial to the heart, and (c) a venous blood vessel in the patient if the patient has a known septal defect; wherein the medical procedure of (a), (b), and (c) comprises release of at least one microembolus in at least one of said heart and blood vessels of (a), (b), and (c) in the body.