主权项 |
1. A c-Jun N-terminal kinase (JNK) inhibitor comprising an inhibitory polypeptide sequence according to the following general formula:X1-X2-X3-R-X4-X5-X6-L-X7-L-X8,(SEQ ID NO: 1) wherein X1 is an amino acid selected from amino acids R, P, Q and r, wherein X2 is an amino acid selected from amino acids R, P, G and r, wherein X3 is an amino acid selected from amino acids K, R, k and r, wherein X4 is an amino acid selected from amino acids P and K, wherein X5 is an amino acid selected from amino acids a, s, q, k or is absent, wherein X6 is an amino acid selected from amino acids T, D and A, wherein X7 is an amino acid selected from amino acids N, n, r and K; and wherein X8 is an amino acid selected from F, f and w, and wherein an amino acid residue given in capital letters indicates an L-amino acid, and an amino acid residue given in lower case letters indicates a D amino acid residue, with the proviso that at least one of the amino acids selected from the group consisting of X1, X2, X3, X7 and X8 is/are a D-amino acid(s). |