| 主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, prodrug, isomer, or tautomer thereof, wherein: each W1 and W2 is independently CH, CF, or N; W3 is CR2, or N; Y1, X1, X2, and Y2 are independently in each occurrence selected from CR6, CR6′, N, NR6′, O, or S, provided that the ring containing Y1, X1, X2, and Y2 cannot have more than 4 N or NH atoms nor more than one S or O atoms, wherein the S and O are not contiguous; R1 is independently H, OH, CN, halogen, CF3, CHF2, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, 3- to 8-membered heterocyclyl, aryl, or heteroaryl, wherein each C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, 3- to 8-membered heterocyclyl, aryl, or heteroaryl is optionally substituted one or more times with substituents selected from halogen, OH, NH2, CN, C1-C6 alkyl, or C1-C6 alkoxy; each R2 is independently H, OH, CN, halogen, CF3, CHF2, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, 3- to 8-membered heterocyclyl, aryl, heteroaryl, NH2, —O(CH2)nR7, —O(CH2)nC(O)NHR7, —O(CH2)nC(O)R7, NHR7, —N(R7)(R8), NHC(O)R7, NHS(O)R7, NHS(O)2R7, NHC(O)OR7, NHC(O)NHR7, —S(O)2NHR7, NHC(O)N(R8)R7, —OCH2R7, —OCHR7R8, or —CHR7R8, wherein C1-C6 alkyl or C1-C6 alkoxy is optionally substituted with one or more substituents selected from C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, 3- to 8-membered heterocyclyl, aryl, -heteroaryl-C(O)NH2, or heteroaryl; R3 is H or C1-C6 alkyl; R4 and R5 are independently H, halogen, CH2OH, C1-C3 alkyl, or C1-C3 alkyl substituted with halogen, or R4 and R5 when combined can form a C3-C5 cycloalkyl or C3-C5 heterocyclyl; R6 and R6′, at each occurrence, are each independently selected from H, OH, CN, —CH2CN, C1-C6 alkyl, —O(CH2)nC(O)NHR7, —O(CH2)nC(O)R7, NHR7, —N(R7)(R8), —NHC(O)R7, —NHS(O)R7, —NHS(O)2R7, —NHC(O)OR7, —NHC(O)NHR7, —S(O)2NHR7, —NHC(O)N(R8)R7, —OCH2R7, R7NHC(O)—, R7S(O)2—, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl, 3- to 8-membered heterocyclyl, aryl, or heteroaryl, wherein each alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl, 3- to 8-membered heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from OH, halogen, oxo, thioxo, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, NH2, CN, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, 3- to 8-membered heterocyclyl, aryl, heteroaryl, or R7S(O)2— or two of R6 and R6′, when adjacent, can be taken together to form an aryl, a 5 to 8-membered heterocyclyl, or 5 to 6-membered heteroaryl, wherein the heterocylcyl or heteroaryl is further optionally substituted with one or more substituents selected from H, OH, CN, oxo, —COOR7, —CH2CN, C1-C6 alkyl, R7S(O)2—, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkenyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, 3- to 8-membered heterocyclyl, aryl, or heteroaryl; R7 and R8 are independently H, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkenyl, C3-C8 cycloalkyl, 3- to 8-membered heterocyclyl, aryl, and heteroaryl; or when combined R7 and R8 can form a 3- to 8-membered heterocyclyl or heteroaryl ring; and n is an integer from 0 to 3; provided that: (1) the compound is not 3-((thiazol-2-ylamino)methyl)quinolin-2(1H)-one; or (2) R1, R2, R3, R4, R5, R6, and R6′ are not all simultaneously H. |
