| 主权项 |
1. A compound of the formula I, in which I1, I2, I3, I4, I5, independently of one another, are N or CR′, T is a phenyl, biphenyl or naphthyl which is unsubstituted or mono-, di- tri- or tetrasubstituted by R, or a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be mono-, di- or trisubstituted by R, ═S, ═NR′ and/or ═O, R1 is isopropyl, 2-butyl or isobutyl, R2 is n-propyl, isopropyl, 2-butyl or isobutyl, A1 is leucine, A2 is valine, L1 is —(C═O)—, L2 is a single bond, X is linear or branched alkyl having 1-10 C atoms or cyclic alkyl having 3-7 C atoms which is unsubstituted or mono- or di-substituted by T, and in which one, two or three CH2 groups may be replaced, independently of one another, by O, Y is OH or O-benzyl, R and R′, independently of one another, are H, linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, Hal, OH, NH2, SO2CH3, SO2NH2, CN, CONH2, NHCOCH3, and/or NHCONH2 and in which one, two or three CH2 groups may be replaced, independently of one another, by O, S, SO, SO2, NH, NCH3, —OCO—, —NHCONH—, —NHCO—, —NRSO2A-, —COO—, —CONH—, —NCH3CO—, —CONCH3—, —C≡C— groups and/or by —CH═CH— groups and/or, in addition, 1-20 H atoms may be replaced by F and/or Cl, or cyclic alkyl having 3-7 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, OH, NH2, SO2CH3, SO2NH2, CN, CONH2, NHCOCH3, and/or NHCONH2 and in which one, two or three CH2 groups may be replaced, independently of one another, by O, S, SO, SO2, NH, NCH3, —OCO—, —NHCONH—, —NHCO—, —NRSO2A-, —COO—, —CONH—, —NCH3CO—, —CONCH3— and/or by —CH═CH— groups and/or, in addition, 1-11 H atoms may be replaced by F and/or Cl, A is an unbranched or branched hydrocarbon chain and has 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, m is 0, n is 1, and Hal is F, Cl, Br or I, or a physiologically acceptable salt, solvate, prodrug or stereoisomer thereof, including mixtures thereof in all ratios. |
