Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases

摘要

This invention is directed to methods of treating diseases or conditions associated with JAK2 activity in a mammal comprising the administration of a compound of formula (I):;
where
;
n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, or a pharmaceutically acceptable salt.

主权项

1. A method of treating, but not preventing, a disease or condition associated with JAK2 activity in a mammal, wherein the method comprises administering to the mammal a therapeutically effective amount of 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, or a pharmaceutically acceptable salt thereof, and the disease or condition is polycythemia vera disorder, essential thrombocythemia disorder or primary myelofibrosis.