发明名称 |
Thiol-ene polymerization with vinylesters and vinylcarbonate |
摘要 |
The present disclosure is directed, in part, to a curable composition, a method for augmenting a structure in a patient with a resorbable biocompatible polymer, and a biodegradable, resorbable implant comprising a biocompatible copolymer. An exemplary embodiment of the curable composition comprises (a) 60 wt. % to 95 wt. % of one or more vinyl ester monomers and/or vinylcarbonate monomers, wherein said one or more vinyl ester monomers and/or vinylcarbonate monomers are respectively selected from compounds of the general formulas (I) and (II) below:;
wherein n, m R1 and R2 have the meaning defined herein; (b) 0.1 to 40 wt. % of one or more multifunctional thiols; and (c) 0 to 10 wt. % of a biocompatible polymerization initiator. |
申请公布号 |
US9623145(B2) |
申请公布日期 |
2017.04.18 |
申请号 |
US201213627399 |
申请日期 |
2012.09.26 |
申请人 |
DePuy Synthes Products, Inc.;Technische Universitaet Wien |
发明人 |
Liska Robert;Qin Xiaohua;Mautner Andreas |
分类号 |
C08F18/04;A61L27/16;C08L33/06;A61L27/54 |
主分类号 |
C08F18/04 |
代理机构 |
Morgan, Lewis & Bockius, LLP |
代理人 |
Morgan, Lewis & Bockius, LLP |
主权项 |
1. A curable composition comprising:
(a) 60 wt. % to 95 wt. % of one or more vinyl ester monomers, wherein said one or more vinyl ester monomers are selected from: (i) a vinyl ester monomer having a formula ofwherein n is an integer from 1 to 12; (ii) monomers selected from diethylene glycol bis[O—(O′-vinylmaleinoyl)-polylactate]) (DVMPL); ω,ω′-3,6,9-trioxaundecanedioic acid divinyl ester (TUVE); polyglutamic acid; polyaspartic acid; hyaluronic acid; polylactic acid; polyglycolic acid; and poly(lactide-co-glycolide); (iii) or combinations thereof;
(b) 0.1 to 40 wt. % of one or more multifunctional thiols selected from the group consisting of ethoxylated pentaerythritol tetra-(3-mercaptopropionate); trimethylpropane tri(3-mercapto-propionate); ethoxylated trimethylpropane tri(3-mercapto-propionate); glycol dimercaptoacetate; trimethylolpropane trimercaptoacetate; pentaerythritol tetramercaptoacetate; ethoxylated trimethylolpropane tri-3-mercaptopropionate; and ethoxylated trimethylolpropane tri-3-mercaptopropionate; polypropylene glycol (3-mercaptopropionate); polypropylene glycol (3-mercaptopropionate);and
(c) 0 to 10 wt. % of a biocompatible polymerization initiator. |
地址 |
Raynham MA US |