| 主权项 |
1. A compound with a structure of Formula (II), or a pharmaceutically acceptable solvate, a pharmaceutically acceptable salt, or a prodrug thereof: wherein m is 0 or 1; n is 0 or 1; L1 is absent, C1-C4alkylene, C1-C4fluoroalkylene, C3-C6cycloalkylene, —C3-C6cycloalkylene-C1-C4alkylene-, C1-C4alkylene-C3-C6cycloalkylene, or —C(R1a)(R1b)—; R1a and R1b are each independently selected from H, C1-C4alkyl and benzyl; R1 is —CO2RD, —C(═O)NHSO2RE, —C(═O)N(RD)2, or tetrazolyl; RD is H or C1-C6alkyl; RE is C1-C6alkyl or a substituted or unsubstituted phenyl; L3 is a substituted or unsubstituted C1-C6alkylene, substituted or unsubstituted C1-C6fluoroalkylene, or substituted or unsubstituted C1-C6heteroalkylene, where if L3 is substituted then L3 is substituted with 1, 2 or 3 R13; each R13 is independently selected from F, C1-C4alkyl, C1-C4fluoroalkyl, hydroxyl, C1-C4alkoxy, C1-C4fluoroalkoxy and a substituted or unsubstituted phenyl; or L3 is -L4-X1-L5-; L4 is absent or a substituted or unsubstituted C1-C4alkylene, where if L4 is substituted then L4 is substituted with 1, 2, or 3 R14; each R14 is independently selected from F, C1-C4alkyl, C1-C4fluoroalkyl, hydroxyl, C1-C4alkoxy and C1-C4fluoroalkoxy; X1 is a absent, —O—, —S—, —S(O)—, —S(O)2—, —NR7—, —C(O)NR8—, —NR8C(═O)—, —NR8C(═O)CH2O—, —NR8C(═O)—CH(CH3)O—, —NR8C(═O)—C(CH3)2O—, —N(R8)S(═O)2—, —S(═O)2N(R8)—, —C(═O)—, —OC(═O)—, —C(═O)O—, —OC(═O)O—, —OC(═O)N(R8)—, —NR8C(═O)O—, or —NR8C(═O)N(R8)—; provided that when L4 is absent then X1 is not —NR8C(═O)O—; R5 is H, or C1-C4alkyl; R7 is H, —S(═O)2R10, —S(═O)2N(R9)2, —C(═O)R10, —CO2R9, —C(═O)N(R9)2, C1-C4alkyl, C1-C4fluoroalkyl, or C1-C4heteroalkyl; R8 is H, C1-C4alkyl, or C1-C4fluoroalkyl; L5 is absent or a substituted or unsubstituted C1-C4alkylene, where if L5 is substituted then L5 is substituted with 1, 2, or 3 R15; each R15 is independently selected from F, C1-C4alkyl, C1-C4fluoroalkyl, hydroxyl, C1-C4alkoxy, and C1-C4fluoroalkoxy; R6 is C1-C6alkyl, C1-C6fluoroalkyl, substituted or unsubstituted C3-C10cycloalkyl, a substituted or unsubstituted C3-C10heterocycloalkyl, a substituted or unsubstituted phenyl, a substituted or unsubstituted naphthyl, a substituted or unsubstituted monocyclic heteroaryl, or a substituted or unsubstituted bicyclic heteroaryl, wherein if R6 is substituted then R6 is substituted with 1, 2 or 3 RC; RC is independently selected from halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R10, —S(═O)2R10, —N(R9)S(═O)2R10, —S(═O)2N(R9)2, —C(═O)R10, —OC(═O)R10, —CO2R9, —OCO2R10, —N(R9)2, —C(═O)N(R9)2, —OC(═O)N(R9)2, —NR9C(═O)N(R9)2, —NR9C(═O)R10, —NR9C(═O)OR10, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4alkoxy, and C1-C4heteroalkyl; each of RA and RB independently, are selected from halogen, —CN, —OH, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4alkoxy, and C1-C4heteroalkyl; each R9 is independently selected from H, C1-C12alkyl, C1-C6heteroalkyl, C1-C6fluoroalkyl, a substituted or unsubstituted C3-C6cycloalkyl, a substituted or unsubstituted C2-C6heterocycloalkyl, a substituted or unsubstituted phenyl, a substituted or unsubstituted monocyclic heteroaryl, —C1-C4alkylene-(substituted or unsubstituted C3-C6cycloalkyl), —C1-C4alkylene-(substituted or unsubstituted C2-C6heterocycloalkyl), —C1-C4alkylene-(substituted or unsubstituted phenyl), or —C1-C4alkylene-(substituted or unsubstituted heteroaryl); or two R9 groups attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted heterocycle; R10 is selected from C1-C6alkyl, C1-C6heteroalkyl, C1-C6fluoroalkyl, a substituted or unsubstituted C3-C6cycloalkyl, a substituted or unsubstituted C2-C6heterocycloalkyl, a substituted or unsubstituted phenyl, a substituted or unsubstituted naphthyl, a substituted or unsubstituted monocyclic heteroaryl, —C1-C4alkylene-(substituted or unsubstituted C3-C6cycloalkyl), —C1-C4alkylene-(substituted or unsubstituted C2-C6heterocycloalkyl), —C1-C4alkylene-(substituted or unsubstituted phenyl), and —C1—C alkylene-(substituted or unsubstituted heteroaryl). |
