Systems and methods for single-molecule detection using nanotubes

摘要

A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the carbon nanotube in the first and second states is compared to detect the presence of a biomolecular entity. A system for single-molecule detection including a carbon nanotube is also provided.

主权项

1. A method for single-molecule detection, comprising:
providing a carbon nanotube having a point defect formed therein and a probe entity attached to the point defect, the probe entity defining a first state of the carbon nanotube, wherein the probe entity comprises a protein; introducing the carbon nanotube to a target entity to define a second state of the carbon nanotube, wherein the target entity comprises a target protein to bind to the protein of the probe entity; comparing the electrical conductance of the carbon nanotube in the first and second states to detect the presence of a biomolecular entity.