| 发明名称 | Mutant NGAL proteins and uses thereof | ||
| 摘要 | In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess iron from the body, for example in the treatment of iron overload. The NGAL mutants of the invention also have antibacterial activity and can be used in the treatment of bacterial infections, such as those of the urinary tract. | ||
| 申请公布号 | US9624281(B2) | 申请公布日期 | 2017.04.18 |
| 申请号 | US201514719204 | 申请日期 | 2015.05.21 |
| 申请人 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 发明人 | Barasch Jonathan;Qiu Andong |
| 分类号 | C12N15/03;A61K35/74;A61K38/00;C07K14/47 | 主分类号 | C12N15/03 |
| 代理机构 | Wilmer Cutler Pickering Hale and Dorr LLP | 代理人 | Wilmer Cutler Pickering Hale and Dorr LLP |
| 主权项 | 1. An engineered polypeptide that comprises the amino acid sequence of SEQ ID NO: 253, wherein said polypeptide is able to bind to a siderophore, and is excreted in the urine of a subject after systemic administration of said polypeptide to the subject. | ||
| 地址 | New York NY US | ||