Methods and therapies for treating inflammatory conditions with exposed collagen

摘要

Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides to regions of exposed collagen in the vasculature or other body lumens. The conversion electron-emitting sources or other radionuclides are coupled to a collagen-binding substance and administered to the vasculature or other body lumen to permit binding for imaging and/or therapeutic purposes.

主权项

1. A method of treating an inflammatory condition in a body lumen, said method comprising:
introducing to the body lumen a therapeutically effective amount of a collagen Type I and/or Type III binding substance bound to no-carrier-added tin-117m during a cascading rupture of vulnerable plaque;
wherein the binding substance specifically binds to Type I and/or Type III collagen exposed within the body lumen as a result of the rupture of vulnerable plaque and wherein the tin-117 m provides therapy to the vulnerable plaque.