发明名称 |
Optical-imaging probe for detecting sentinel lymph nodes which contains a composite of poly-gamma-glutamic acid and an optical-imaging dye |
摘要 |
The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body. The use of the poly-gamma-glutamic acid/fluorescent dye complex makes it possible to accurately detect the position of a sentinel lymph node in real time without concerns about radioactive contamination. |
申请公布号 |
US9623121(B2) |
申请公布日期 |
2017.04.18 |
申请号 |
US201113885126 |
申请日期 |
2011.11.18 |
申请人 |
BIOLEADERS CORPORATION;THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY;KOOKMIN UNIVERSITY INDUSTRY - ACADEMIC COOPERATION FOUNDATION |
发明人 |
Sung Moon-Hee;Lim Yong Taik;Noh Young-Woock;Lee Il Han |
分类号 |
A61B5/055;A61K49/00;G01N21/64 |
主分类号 |
A61B5/055 |
代理机构 |
Hultquist, PLLC |
代理人 |
Hultquist, PLLC ;Hultquist Steven J. |
主权项 |
1. An optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and indocyanine green (ICG),
wherein a negative charge of the indocyanine green (ICG) is hydrophobically coupled to hydrophobic moiety of the poly-gamma-glutamic acid in an aqueous solution, the poly-gamma-glutamic acid has a molecular weight of 10-15000 kDa, and a concentration of the complex of poly-gamma-glutamic acid and indocyanine green (IGC) depends on a molecular weight of the poly-gamma-glutamic acid. |
地址 |
Daejeon KR |