Bacteriophages

摘要

The present invention provides a bacteriophage with effective antibacterial activity against Staphylococcus strains and in particular MRSA. There is also provided a pharmaceutical composition comprising said bacteriophage and a method of treating a bacterial infection using a composition comprising said bacteriophage.

主权项

1. A Staphylococcus bacteriophage K mutant, which comprises one or more mutations within one or more of the following regions, corresponding to the nucleotide sequence of wild-type Staphylococcus bacteriophage K, selected from:
a) the region between ORF 18 and ORF 19; and/or b) the region between ORF 41 and ORF 42; and/or c) ORF 68; and/or d) an overlapping region within ORF 86/88/90; and/or e) ORF 92; and/or f) ORF 93; and/or g) ORF 96; and/or h) ORF 100.