Diagnosis of neurodegenerative disorders

摘要

Methods are provided for non-invasive early screening of a subject for a neurodegenerative disorder, by analyzing one or more parameters associated with the neurodegenerative disorder.

主权项

1. A method of detecting an increased risk of developing Parkinson's disease or Parkinson's-like disease indicated by a loss of standard deviation of heart rate (SDHR), said method comprising:
a) selecting a subject that does not exhibit motor symptoms indicative of Parkinson's disease or Parkinson's-like disease; b) obtaining 5 or fewer minutes of heart rate data; c) determining a SDHR of said subject from the heart rate data; d) detecting the increased risk for developing Parkinson's disease or Parkinson's-like disease if said SDHR of said subject is less than a control SDHR; and e) taking a sample for genetic testing, if the increased risk for developing Parkinson's disease or Parkinson's-like disease has been detected in said subject in step d).