Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof

摘要

Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):;

主权项

1. A method for treating glioblastoma multiforme, comprising administering to a subject having glioblastoma multiforme an effective amount of Pyrrolopyrimidine Compound, wherein the Pyrrolopyrimidine Compound is a compound of formula (I): and pharmaceutically acceptable salts, tautomers, stereoisomers, enantiomers, and isotopologues thereof, wherein: R1 is substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C3-8 cycloalkyl, or substituted or unsubstituted non-aromatic heterocyclyl; R2 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted heterocyclyl or substituted or unsubstituted aryl, and L is NH or O; provided R3 is not pyridyl when L is NH or when R2 is pyrazolyl; and the compound is not N-methyl-N-[trans-3-[[5-(1-methyl-1H-pyrazol-4-yl)-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]cyclobutyl]-2-propenamide; or N-methyl-N-[trans-3-[[5-(1-methyl-1H-pyrazol-3-yl)-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]cyclobutyl]-2-propenamide.