Preparation of desiccated liposomes for use in compressible delivery systems

摘要

The present document describes a compressible delivery formulation for transmucosal delivery of at least one compound which includes a micronized powder base; and a desiccated liposome formulation comprising at least one liposome containing at least one compound, process of making the same and process for making dosage forms from the formulation.

主权项

1. A process for the preparation of a formulation for transmucosal delivery of at least one compound comprising:
a) spraying a liposome formulation suspended in a water based solvent on a micronized powder base, said liposome formulation comprising at least one liposome containing at least one compound in an amount sufficient to form a unitary dosage form containing from about 10 μg to about 500 mg of said compound, at a temperature at a nozzle head aperture of about 60° C. or less to evaporate said water based solvent and desiccate said liposome, wherein about 0.4 L to about 1.0 L of said liposome formulation suspended in a water based solvent is sprayed per about 1 kg of said micronized powder base.