| 主权项 |
1. A method for treating a disease in a human selected from cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infaction, atheroscleosis, Type I or 2 diabetes, obesity, inflammatory disease, or Myc-depenent disorder comprising administering a compound of Formula I-IX: wherein M is oxygen (O) or sulfur (S); R1 is selected from H, halogen, alkyl, alkenyl, alkynyl, carbocycle, aryl, heterocycle, heteroaryl, formyl, nitro, cyano, amino, carboxylic acid, carboxylic ester, carboxyl amide, reverse carboxyamide, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted carbocycle, substituted aryl, substituted heterocycle, substituted heteroaryl, phosphonic acid, phosphinic acid, phosphoramidate, phosphonic ester, phosphinic ester, ketone, substituted ketone, hydroxamic acid, N-substituted hydroxamic acid, O-substituted hydroxamate, N- and O-substituted hydroxamate, sulfoxide, substituted sulfoxide, sulfone, substituted sulfone, sulfonic acid, sulfonic ester, sulfonamide, N-substituted sulfonamide, N,N-disubstituted sulfonamide, boronic acid, boronic ester, azo, substituted azo, azido, nitroso, imino, substituted imino, oxime, substituted oxime, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, thioether, substituted thioether, carbamate, substituted carbamate; R2 is selected from R1 or where X is C, N, P, P(O), SiRb, n is 0, 1, or 2; Y is C—R1, O, S, NRa, —C(O)(NH2), —P(Z)mRa, SiRaRb, BRb; Z is O or S; m=0 or 1; Ra is hydrogen (H) or independently at each instance any group defined in R1; Rb is hydrogen (H) or independently at each instance any group defined in R1; R3 is selected from R1; R4 is selected from R1; and
Cyc is an aryl, substituted aryl, heterocyele, substituted heterocycle, carbocycle, and substituted carbocycle. |
