BIOMARKERS FOR PREDICTING OUTCOMES OF CANCER THERAPY WITH ERBB3 INHIBITORS

摘要

Methods for predicting a therapeutic response in a patient (e.g., a cancer patient) to ErbB3 inhibitors, and methods of treating a cancer patient with targeted therapies.

主权项

1. A method of treating a patient having a heregulin positive (HRG+) cancer with a solid tumor having a ratio of expressed ErbB4 to ErbB3 of less than 1.3, the method comprising: administering a therapeutically effective amount of an anti-ErbB3 antibody to the patient, wherein the anti-ErbB3 antibody comprises CDRH1, CDRH2, and CDRH3 sequences comprising the amino acid sequences set forth in SEQ ID NO:1 (CDRH1), SEQ ID NO:2 (CDRH2), and SEQ ID NO:3 (CDRH3); and CDRL1, CDRL2, and CDRL3 sequences comprising the amino acid sequences set forth in SEQ ID NO:4 (CDRL1), SEQ ID NO:5 (CDRL2), and SEQ ID NO:6 (CDRL3).