CHEMOKINE RECEPTOR BINDING POLYPEPTIDES

摘要

The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

主权项

1. A polypeptide binding to the chemokine receptor CXCR2, comprising at least two immunoglobulin antigen binding domains, wherein said polypeptide includes a first antigen binding domain recognising a first epitope on CXCR2 and a second antigen binding domain recognising a second epitope on CXCR2.