发明名称 |
COMPOSITIONS OF A POLYORTHOESTER AND AN APROTIC SOLVENT |
摘要 |
Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release. |
申请公布号 |
US2017100483(A1) |
申请公布日期 |
2017.04.13 |
申请号 |
US201615269806 |
申请日期 |
2016.09.19 |
申请人 |
Heron Therapeutics, Inc. |
发明人 |
Ottoboni Thomas B.;Schillinger Lee Ann Lynn;Niemann Joseph |
分类号 |
A61K47/34;A61K47/20;A61K47/22;A61K47/10;A61K31/439 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
|
主权项 |
1. A delivery system, comprising:
a polyorthoester; an aprotic solvent in which the polyorthoester is miscible to form a single phase; and a therapeutically active agent dispersed or solubilized in the single phase; wherein the active agent is released from the system over a period of between approximately 1 day and approximately 8 weeks. |
地址 |
Redwood City CA US |