AMPLIFICATION OF EPITOPE SPECIFIC PERSONALIZED ANTI-ANGIOGENIC IMMUNE RESPONSES

摘要

Disclosed are therapeutic means, protocols, and compositions of matter useful for treatment of cancer by eliciting and amplifying immune responses specific to antigens found on tumor endothelium. In one embodiment of the invention a patient is immunized with a polyvalent anti-angiogenic vaccine, subsequent to which assessment is made in a patient specific manner of the immune targets that are recognized in response to the immunizing mixture. Subsequently immune targets that are identified are chosen for antigen-specific immunization to amplify initial immune response stimulated by the polyvalent vaccination.

主权项

1. A method of amplifying an anti-angiogenic immune response comprising the steps of: a) immunizing a cancer patient with a polyvalent antiangiogenic vaccine; b) assessing immune response of said cancer patient to a panel of antigens known to be associated with angiogenesis; and c) immunizing said patient with monovalent antigens to which an immune response has been identified subsequent to initial immunization with said polyvalent antiangiogenic vaccine.