| 发明名称 |
MODIFIED NATURAL KILLER CELLS HAVING ANTI-FUGETACTIC PROPERTIES AND USES THEREOF |
| 摘要 |
This invention provides ex vivo methods for making modified natural killer cell compositions having overall anti-fugetactic properties for the effective and efficient treatment of tumors or cancers in a patient, and compositions and use thereof. |
| 申请公布号 |
US2017100433(A1) |
申请公布日期 |
2017.04.13 |
| 申请号 |
US201615268426 |
申请日期 |
2016.09.16 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL |
发明人 |
POZNANSKY Mark C.;VIANELLO Fabrizio |
| 分类号 |
A61K35/17;A61K39/395;C12N5/0783;A61K31/395 |
主分类号 |
A61K35/17 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An ex vivo natural killer (NK) cell population comprising modified NK cells, said NK cell population having an anti-fugetactic agent bound to individual NK cells through a receptor on the cell surface, wherein said NK cell population exhibits overall anti-fugetactic properties relative to a cancer when delivered to a patient in vivo. |
| 地址 |
Boston MA US |
