发明名称 |
DEPTH ENHANCED AND FLUORESCENCE LIFETIME STIMULATED FLUORESCENT EMISSION FOR IN-VIVO IMAGING |
摘要 |
The specification relates to a microscopy system. The microscopy system includes a first laser emitting a first laser pulse, the first laser pulse being a pump beam; a second laser emitting a second laser pulse, the second laser pulse being a probe beam; time delay components for delaying the probe beam, wherein the time delay components delay the probe beam by 0.3 ps to 5 ns relative to the pump beam; an optical device for combining the pump beam and the delayed probe beam into a combined laser pulse, the combined laser pulse having a reduced focal spot size; a galvanometer scanning system for delivering the combined laser pulse to a focal spot in a focal plane, wherein the reduced focal spot size of the combined laser pulse initiates a stimulated emission of a targeted molecule, the stimulated emission having dipole-like backscatter, and a detector for detecting the dipole-like backscatter. |
申请公布号 |
US2017102532(A1) |
申请公布日期 |
2017.04.13 |
申请号 |
US201514949612 |
申请日期 |
2015.11.23 |
申请人 |
Frankel Robert David |
发明人 |
Frankel Robert David |
分类号 |
G02B21/00;A61B5/00;H01S3/094;G02F1/35;G02F1/225;G02F1/11 |
主分类号 |
G02B21/00 |
代理机构 |
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代理人 |
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主权项 |
1. A microscopy system comprising:
a first laser emitting a first laser pulse, the first laser pulse being a pump beam; a second laser emitting a second laser pulse, the second laser pulse being a probe beam; a time delay component for delaying the probe beam, wherein the time delay components delay the probe beam by 0.3 ps to 5 ns relative to the pump beam; an optical device for combining the pump beam and the delayed probe beam into a combined laser pulse, the combined laser pulse having a reduced focal spot size; a galvanometer scanning system for delivering the combined laser pulse to a focal spot in a focal plane, wherein the reduced focal spot size of the combined laser pulse initiates a stimulated emission of a targeted molecule, the stimulated emission having dipole-like backscatter, and a detector for detecting the dipole-like backscatter. |
地址 |
Rochester NY US |