METHODS OF ENHANCING T-CELL LONGEVITY AND USES THEREOF

摘要

The present disclosure encompasses methods of enhancing T cell longevity and/or T cell function by promoting mitochondrial fusion and/or mitochondrial structural remodeling including cristae. Compositions comprising the enhanced T cells may be used in adoptive cellular immunotherapy.

主权项

1. A method to promote T-cell longevity, the method comprising culturing T cells in the presence of a composition comprising one or more compounds to promote mitochondrial fusion and/or mitochondrial structural remodeling including cristae.