| 发明名称 |
PREDICTING AND REDUCING COGNITIVE DECLINE BASED ON GSK-3 LEVELS |
| 摘要 |
Materials and methods for predicting cognitive decline based on total or active/inactive levels of markers such as GSK-3 are provided. Materials and methods for preventing or delaying the onset of cognitive decline in individuals identified as being in need thereof also are provided. |
| 申请公布号 |
US2017102398(A1) |
申请公布日期 |
2017.04.13 |
| 申请号 |
US201515122991 |
申请日期 |
2015.03.05 |
| 申请人 |
HUMANETICS CORPORATION |
发明人 |
KAYTOR Michael D.;DYKSTRA John C. |
| 分类号 |
G01N33/68;A23L33/105;A61K31/075 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for promoting neurological health in a subject, comprising:
obtaining a measured level of glycogen synthase kinase-3 (GSK-3) in a biological sample from the subject, wherein the measured level of GSK-3 is the level of total GSK-3, the level of phosphorylated GSK-3, the level of non-phosphorylated GSK-3, the ratio of phosphorylated GSK-3:total GSK-3, or the ratio of phosphorylated GSK-3:non-phosphorylated GSK-3; comparing the measured level of GSK-3 to a corresponding control level of GSK-3; and if the measured level is at least 25 percent higher or lower than the control measured level, treating the subject with D-pinitol. |
| 地址 |
Edina MN US |
