MIRNA BIOMARKERS FOR MONITORING BONE MARROW RECONSTITUTION

摘要

Disclosed herein are compositions and methods for monitoring hematopoietic reconstitution or suppression in a subject. Also disclosed are compositions and methods for reconstituting the hematopoietic compartment of a subject in need thereof. Also disclosed is a method for monitoring the effect of ionizing radiation on the lung in a subject. Also disclosed is the ability to use detection of the one or more microRNA indicative of radiation-induced lung injury to guide therapy of the subject. Also disclosed is the ability to use detection of the one or more microRNA indicative of radiation-induced lung injury to evaluate the efficacy of a lung treatment following radiation exposure.

主权项

1. A method for monitoring hematopoietic reconstitution or suppression in a subject, comprising quantifying the levels of circulating miR-150 in a cell-free blood sample from a subject recipient of a population of hematopoietic stem cells, wherein the levels of circulating miR-150 in the sample is a measure of hematopoietic reconstitution or suppression.