发明名称 NOVEL COMPOUNDS
摘要 The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ
申请公布号 US2017101399(A1) 申请公布日期 2017.04.13
申请号 US201515314107 申请日期 2015.05.26
申请人 GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED 发明人 LEI Hui;MA Xin;REN Feng;LIN Xichen;MARQUIS, JR. Robert W.
分类号 C07D405/06;C07D417/14;C07D405/14 主分类号 C07D405/06
代理机构 代理人
主权项 1. A compound of Formula I or a pharmaceutically acceptable salt thereof:wherein R1 is: 5 to 6 membered monocyclic heteroaryl optionally substituted with i) C1-C5 alkyl optionally substituted with CF3 or CN, ii) CH2F; or iii) one to two substituents independently selected from the group consisting of halo, methyl, methoxy and CN; wherein said 5 to 6 membered monocyclic heteroaryl is selected from the group consisting of pyrrolyl, pyrazolyl, Imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, furanyl, furazanyl, thienyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, tetrazinyl, and tetrazolyl, or N-oxides thereof; orphenyl substituted with one to two substituents independently selected from the group consisting of CN, halo and methyl; R2 is C1-C3 alkyl; R3 is halo, R4 is H; R5 is C1-C3 alkyl, R6 is H or methyl; and R7 is tetrahydrofuranyl or tetrahydropyranyl, wherein said tetrahydrofuranyl or tetrahydropyranyl is optionally substituted with methyl.
地址 Middlesex GB