Combination

摘要

The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering a proteasome inhibiting compound, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents, to a human in need thereof.

主权项

1. A combination comprising:
(i) a compound of Structure (I): and (ii) a compound of Structure (II): optionally in the form of a monohydrochloride salt, and (iii) optional additional antineoplastic agents; where the amount of the compound of Structure (I) is an amount selected from 1.35 to 2.0 mg/m2, and that amount is administered intravenously or subcutaneously once per week.