Device and Method for Non-Invasive Measuring of Analytes

摘要

The present disclosure relates to devices and methods for non-invasive measuring of analytes. At least one embodiment relates to a wearable system for non-invasive measuring of a concentration of an analyte in skin tissue. The wearable system includes an integrated circuit that includes a first optical unit. The first optical unit includes a Raman spectrometer. The first optical unit also includes an OCT spectrometer and an interferometer optically coupled to the OCT spectrometer or an infrared (IR) spectrometer. The first optical unit additionally includes a light coupler. The wearable system further includes a first light source for performing Raman spectroscopy. The wearable system additionally includes a second light source for performing OCT spectroscopy or IR spectroscopy. Still further, the wearable system includes read-out electronics to determine an optical model of the skin tissue based on the spectroscopic data and to determine the concentration of the analyte.

主权项

1. A wearable system for non-invasive measuring of a concentration of an analyte in skin tissue, comprising:
an integrated circuit comprising a first optical unit, wherein the first optical unit comprises:
a Raman spectrometer;an OCT spectrometer;an interferometer optically coupled to the OCT spectrometer or an infrared spectrometer; anda light coupler positioned to couple scattered or reflected light from illuminated skin tissue into the Raman spectrometer and into one or both of the OCT spectrometer and the infrared (IR) spectrometer; and a first light source optically coupled to or integrated in the integrated circuit and configured to emit a laser beam for performing Raman spectroscopy; a second light source optically coupled to or integrated in the integrated circuit and configured to emit a broadband light beam for performing OCT spectroscopy or IR spectroscopy; and read-out electronics electrically coupled to the integrated circuit and configured to read out spectroscopic data from the Raman spectrometer, to read out spectroscopic data from one or both of the OCT spectrometer and the IR spectrometer, to determine an optical model of the skin tissue based on the spectroscopic data from the OCT spectrometer or the IR spectrometer, and to determine the concentration of the analyte based on a correlation between the spectroscopic data from the Raman spectrometer and the determined optical model of the skin tissue.